Jinghua Wang, PhD

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Jinghua Wang

Assistant Professor

My scientific pursuits have culminated in a passion for developing computer-aided tools to complement and support the radiologists’ diagnosis and decision-making. Artificial intelligence (AI) techniques will support more efficient and accurate diagnoses and better treatment options. However, the differences in MRI image acquisitions due to manufacturers, field strengths, patient motion, coil and imaging parameters lead to inconsistent appearance and quality of MRI images. These differences pose significant challenges for current machine learning algorithms, leading to reduced accuracy and precision of image interpretation. To solve this challenge, it is necessary to optimize and standardize the pre-processing of images (i.e. inhomogeneity correction, signal normalization, registration to standard template, geometry distortion correction) to reduce the variability of images across centers and scanners. Over the last two decades, I have been working on MRI signal computer simulation, magnetic field estimation, sequence optimization, artifact reduction. Learn More

Biography & Affiliation

Research Interests

medical image processing and analysis

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Education

Post-doc Research

Yale School of Medicine

Doctor of Philosophy (Ph.D.)

Physics, Institute of Physics Chinese Academy of Sciences, China, 1996.

Master of Science (M.S.)

Physics, Peking University, China, 1991.

Bachelor of Science (B.S)

Physics, Jiling University, China, 1986.

Publications
  • Chen M, Li H, Wang J, Dillman JR, Parikh NA, and He L. A multi-channel deep neural network model analyzing multiscale functional brain connectome: application to ADHD classification. Radiology: Artificial Intelligence, 2019;2(1), e190012. PMC Journal
  • Li H, Parikh NA, Wang J, Merhar S, Chen M, Parikh M, Holland SK, He L. Objective and automated detection of diffuse white matter abnormality in preterm infants using deep convolutional neural networks. Frontiers in Neuroscience. 2019;13(610). PMC Journal
  • He L, Wang J, Lu ZL, and Parikh NA. Optimization of Neonatal Magnetization-Prepared Rapid Gradient Echo (MP-RAGE) Sequence with Shorter Acquisition Train Length. Pediatr Radiol. 2018;48(8):1139-1151.
  • Wang J, He L, Zheng HR, Lu ZL. Improving image quality of structural brain images acquired with 3D FLASH sequence. Magnetic Resonance Imaging 2017;38:224-232 Pubmed Journal
  • Wang J, He L, Lu ZL. Optimization of Magnetization-prepared Rapid Gradient-echo (MP-RAGE) Sequence at 3.0 T. PLOS ONE. 2014;9: e96899 PMC Journal
  • Yang QX, Wang J, Wang J, Collins CM, Wang C, Smith MB. Reducing SAR and Enhancing Cerebral SNR with High Permittivity Padding at 3 T. Magn. Reson. Med. 2011;65:358-62. Pubmed Journal
  • Qiu M, Maguire RP, Arora J, Planeta-Wilson B, Weinzimmer D, Wang J, Wang Y, Kim H, Nallakkandi R, Huang Y, Carson RE, Constable RT. Arterial Transit Time Effects in Pulsed Arterial Spin Labeling CBF Mapping: Insight from a PET and MR Study in Normal Human Subjects. Magn. Reson. Med. 2010;63:374-84. PMC Journal
  • Kim H, Pinus AB, Wang J, Murphy PS, Constable RT. On the Application of Chemical Shift-Based Multipoint Water-Fat Separation Methods in Balanced SSFP Imaging. Magn Reson Med. 2007;58:413-8. PMC Journal
  • Wang J, Mao W, Qiu M, Smith MB, Constable RT. Factors influencing flip angle mapping in MRI: RF pulse shape, slice-select gradients, off-resonance excitation, and B0 inhomogeneities. Magn. Reson. Med. 2006;56:463-468. Pubmed Journal
  • Wang J, Qiu M, Kim H, Constable RT. T1 Measurements Incorporating Flip Angle Calibration and Correction In Vivo. J Magn. Reson. 2006:182:283-292. Pubmed Journal
  • Yang QX, Mao W, Wang J, Smith MB, X Zhang, Ugurbil K, W Chen. Manipulation of Image Intensity Distribution at 7.0 T: Passive RF Shimming and Focusing with Dielectric Materials. J Magn Reson. Inamging. J Magn Reson Imaging. 2006;24:197-202. Pubmed Journal
  • Wang J, Qiu M, Yang QX, Smith MB, Constable RT. Correction of Transmission and Reception Fields Induced Signal Intensity Nonuniformities In Vivo. Magn. Reson. Med. 2005;53:408-417. Pubmed Journal
  • Wang J, Qiu M, Constable RT. A Method For Rapid And Effective Correction of Signal Intensity Nonuniformities with Phased Array Coils In Vivo. Magn. Reson. Med. 2005;53:666-674. Pubmed Journal
  • Yang QX, Wang J, Collins CM, Smith MB, Zhang X, Ugurbil K, Chen W. Phantom Design Method for High-Field MRI Human Systems. Magn. Reson. Med. 2004; 52:1016-1020. Pubmed Journal
  • Zheng J, Wang J, Rowold F, Gropler RJ, Woodard PK. Relationship of Apparent Myocardial T2 and Oxygenation: Towards Quantification of Myocardial Oxygen Extraction Fraction. J Magn Reson Imaging. 2004;20:233-241. Pubmed Journal
  • Collins CM, Liu WZ, Wang J, Gruetter R, Vaughan JT, Ugurbil K, Smith MB. Temperature and SAR Calculations for a Human Head within Volume and Surface Coils at 64 and 300 Mhz. J Magn Reson Imaging. 2003; 19; 650-656. Pubmed Journal
  • Wang J, Yang QX, Collins CM, Smith MB, Zhang X, Liu H, Adriany G, Zhu XH, Vaughan JT, Ugurbil K, Chen W. Polarization of the RF field in a human head at high field: a study with a quadrature surface coil at 7.0 T. Magn Reson. Med. 2002;48:362-369. Pubmed Journal
  • Zheng J, Wang J, Nolte M, Rowold F, Yablonskiy DA, Woodard PK, Li D, Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: a preliminary study in canines. Magn. Reson. Med. 2004;51:718-726. Pubmed Journal
  • Yang QX, Wang J, Zhang X, Collins CM, Smith MB, Liu H, Zhu XH, Michaeli S, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Chen W. An Analysis of Wave Behavior in Lossy Dielectric Samples at High Field. Magn Reson. Med 2002;47:982-989. Pubmed Journal
  • Collins CM, Yang QX, Wang J, Zhang X, Liu H, Michaeli S, Zhu XH, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Smith MB, Chen W. Different Excitation and Reception Distributions with a Single-Loop Transmit-Receive Surface Coil near a Head-Sized spherical phantom at 300 MHz. Magn Reson. Med. 2002;47:1026-1028. Pubmed Journal
  • Bus SA, Yang QX, Wang J, Smith MB, Wunderlich R, Cavanagh PR. Intrinsic Muscle Atrophy and Its Relationship to Claw Toe Deformity in Diabetic Patients with Neuropathy: an MRI Study. Diabetes Care. 2002;25:1444-50. Journal